Chronic kidney disease is one of the most underestimated public health challenges of the twenty-first century. Affecting an estimated 850 million people worldwide, CKD progresses silently in the vast ...
Kidney transplantation remains the optimal treatment for eligible patients with end-stage renal disease. However, the lifelong requirement for immunosuppressive therapy introduces significant risks of...
Acute kidney injury (AKI) is a common and serious clinical syndrome associated with significant morbidity and mortality, particularly in hospitalized and critically ill patients. Traditionally defined...
Prevention of CKD onset and progression is a critical public health priority. The ISN Global Kidney Health Roadmap (Levin et al., Kidney International, 2023) identified CKD prevention, early detection...
IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide and a leading cause of CKD progression to end-stage renal disease. The four-hit pathogenesis model, consolidated by Wy...
The discovery of phospholipase A2 receptor (PLA2R) as the primary target antigen in primary membranous nephropathy (MN) by Beck et al. (New England Journal of Medicine, 2009) transformed the clinical ...
For the millions of people worldwide living with end-stage renal disease (ESRD), dialysis is not merely a medical procedure — it is a lifeline. While hemodialysis remains the most widely used form of ...
Lupus nephritis (LN) is among the most consequential manifestations of systemic lupus erythematosus (SLE), a chronic autoimmune disease that can affect virtually every organ system. When lupus targets...
Kidney failure, in its most advanced form, is not simply a medical diagnosis. It is a life-altering event that confronts patients with a stark and often unfair choice: access expensive, lifelong treat...
End-stage renal disease (ESRD) constitutes a growing global health and economic burden. The United States Renal Data System (USRDS) Annual Data Report 2022 documented incident treated ESRD rates of ap...