SCIENTIFIC PROGRAM
XVth International Congress of Nephrology
XIth Latinamerican Congress of Nephrology
May 2 -6, 1999, Buenos Aires, Argentina
Industry Sponsored
Symposia and Novel Therapeutics in Nephrology, May 1-5
Program of Monday, May 3
Program of Tuesday, May 4
Program of Wednesday, May 5
Program of Thursday, May 6
INDUSTRY SPONSORED SYMPOSIA, May 1- 5, 1999
May 1, 16:30-19.00 hr.
CARDIOVASCULAR RISK FACTORS: IMPACT ON RENAL DISEASE
Libertador A room
Chairperson: M. Epstein, US
Welcome and Introduction
M. Epstein, US
Diabetes and Hypertension: Implication of Co-existing Morbidities
M. Cooper, Australia
Determinants of Progressive Renal Disease in Diabetes and Optimal Therapeutic
Treatments
H. Parving, Denmark
Perspectives
M. Epstein, US
Endothelial Dysfunction: Implications for Hypertension and Renal Disease
E. Schiffrin, Canada
The Role of Lipids in Renal Disease
G. Kaysen, US
Discussion, Summary and Conclusions
May 2,
10:30-12:30 hr.
IMPROVING LONGTERM OUTCOME IN KIDNEY TRANSPLANTATION
Libertador A room
Chairperson: T. Mathew, Australia
lmmunosuppression: The Challenge of Toxicity
B. Nashan, Germany
New Insights into Mechanisms of Toxicity
J. Campistol, Spain
Eliminating Nephrotoxicity of Immunosuppression
J. Morales, Spain
Optimizing Immunosuppressive Strategies in Kidney Transplantation
V. McAllister, Canada
web site
May 2, 14:30-17:00 hr
REMISSION/REGRESSION STRATEGIES IN CHRONIC RENAL DISEASE
Libertador A room
Chairpersons:
B. Brenner, US
J. Herrera-Acosta, Mexico
Introductory Remarks
B. Brenner, US
Pathogenic Mechanisms of Renal Disease Progression
W.F. Keane, US
Pathogenic Significance of Microalbuminuria
H.H. Parving, Denmark
Remission Strategies, 1999
G. Remuzzi, Italy
Remission Strategies in 2000 and Beyond
M. Pohl, US
Remission/Regression of Renal Disease will Require Multiple Modality
Strategies
B.M. Brenner, US
Discussion
web site Merck Sharp and Dome
May
2, 14:30-17:00 hr.
STAY ON THERAPY: THE RATIONALE FOR USE OF LOSARTAN IN RENAL
PROTECTION
Libertador C room
Chairperson:
L. Ruilope, Spain
A. Ribeiro, Brazil
Introduction: Dissatisfaction with Current Antihypertensive Therapy
L. Ruilope, Spain
COZAAR Renal All Investigator Award Lecture: Angiotensin 11 Receptor Antagonist
(Losartan) Decreases Plasma Levels of TGB in Transplant Patients with Chronic
Allograft Nephrology
J. Campistol, Spain
TGF-B in the Progression of Renal Disease: Role of All Blockade
W. Border, US
The Role of Uric Acid in Cardiovascular Disease
R. Johnson, US
Losartan in Prevention of Microvasculopathy
M. Cooper, Australia
Angiotensin 11 Antagonists and Renal Transplantation
G. Remuzzi, Italy
Is All Antagonism the Best Way to Treat Diabetic Renal Disease?
L. Ruilope, Spain
Closing Statements
A. Ribeiro, Brazil
Novel Therapeutics in Nephrology
May
3, 19:00-20.00 hr.
AT1 - RECEPTOR BLOCKADE: A NOVEL THERAPEUTIC
APPROACH
Libertador B room
Chairperson:
C. Johnston, Australia
L. Ruilope, Spain
Introduction:
C. Johnston, Australia
Renal Functional Responses to A Tl Receptor Blockade in
Normal and Hypertensive States
G. Navar, Spain
The Importance ofRAS in the Progression of Chronic Renal Failure
C. Johnston, Australia
The Role of RAS Blockade in Reducing Cardiac and Renal Risk
L. Ruilope, Spain
May
4, 19:00-20:00 hr.
HYPERTENSION AND RENAL DISEASE: A CASE FOR RIGOROUS
TREATMENT
Libertador B room
Chairperson:
M. Epstein, US
web site Total Renal Care
May 4, 19:00-20:00 hr.
CARDIOVASCULAR DISEASE AND CHRONIC RENAL INSUFFICIENCY: IMPLICATIONS
FOR FUTURE
Libertador C room
Chairperson:
W. Keane, US
S. Massey, US
The National Kidney Foundation Initiative on Cardiovascular Disease: Pathogenesis
and Treatment
J. Kopple, US
Proteinuria: A Risk Factor for Cardiovascular Morbidity and Mortality in
Diabetes and Non-Diabetic Patients
W. Keane, US
The Influence of Anemia on Cardiovascular Morbidity and Mortality
A. Collins, US
The Role of Homocysteine as a Risk Factor for Cardiovascular Disease
C. Wilcox, US
web site Chugai
May 5, 19:00-20:00 hr.
NEW VITAMIN DERIVATIVE 22-OXA-CALCITRIOL IN THE MANAGEMENT OF UREMIC
HYPERPARATHYROIDISM
Libertador A room
Chairperson:
E. Ogata, Japan
Assessment of 22-Oxa-Calcitriol
E. Slatopolsky, US
Results of Clinical Trials
T. Akizawa, Japan
web site
May 4, 19:00-20:00 hr.
CONTINUOUS ASSESSMENT OF HEMODIALYSIS THERAPY
Libertador C room
Theoretical Background
F. Gotch, US
Clinical Results
F. Locatelli, Italy
SYMPOSIA 08:00-10:00 hr
MECHANISMS OF GLOMERULAR DISEASES
Libertador Room
Chairpersons:
S. Mezzano, Chile
D. Schl�ndorff, Germany
Immunohistological insights in the pathogenesis of glomerulonephritis
C. Alpers, US
Monocytes and glomerulonephritis
R. Atkins, Australia
Cytokines and glomerulonephritis
J. Fioege, Germany
Mechanisms of proteinuria
D. Kedaschki, Austria
POLYCYSTIC KIDNEY DISEASE
Retiro Room
Chairpersons:
J. Grantham, US
R. S. Martin, Argentina
Genetic basis
P. Harris (supported by Polycystic Kidney research Foundation)
Pathogenesis of cyst formation
J. van Adelsberg, US
Management of extra-renal problems
J-P. Gr�nfeld, France
Management of renal problems
V. Torre, US
NEPHROLOGY IN THE INTENSIVE CARE UNIT
San Telmo Room
Chairpersons:
J. Ayus, US
W Suki, US
Controversies in the management of lactic acidosis
A. Ariett, US
Management of hypercalcemic crisis
W. Suki, US
Role of gender and hypoxia on hyponatremic
encephalopathy
J. Ayus, US
Management of hypervolemia
C. Ronco, Italy
CHANNELS AND TRANSPORTERS
Golden Horn Room
Chairpersons
S. Herbert, US
G. Malnic, Brazil
Sodium bicarbonate cotransporters
W. Boron, US
Regulation of chloride channels in the kidney
S. Uchida, Japan
Regulations of Na-K-2CL cotransporters
G. Gamba, Mexico
Regulation of the Na-H exchangers
S. Grinstein, Canada
COFFEE BREAK
10:00-10:30 hr
PLENARY SESSION
10:30-11:30 hr
The Donald W. Seldin Lecture
CYTOKINES AND CHEMOKINES (supported by Chugai
Parm. Co. LTD)
Lecturer Tadamitsu Kishimoto (Japan)
Introduced by K. Kurokawa
Libertador, Retiro and San Telmo Rooms
*(Note Video Legacy Conversation with Dr. Donald Seldin Thursday 7-8 P.M. Libertador B Room)
POSTER SESSION
11:30-14:00 hr (11:30-12:30 poster discussion) Catalinas and San lsidro Rooms
SLANH SYMPOSIUM
11:30-14:00 hr
PROGRESION Y NEFROPROTECCION (sponsored by Hoechst Marion Roussel SA)
President:
P. Massari, Argentina
L. Juncos, Argentina
Mechanismos de progresi�n: una vision global
S. Klahr, US
Polimorfismo de la enzima de conversi�n y su impacto en /a progresi�n
D. Hernandez, Spain
Detecci�n y prevenci�n precoz en hipertensi�n arterial
R. Sanchez, Argentina
El papel de la hipertensi�n en la insuficiencia renal cr�nica
M. Martinez Maldonado, US
lntervenci�n farmaco1�gica con drogas vasoactivas
G. Remuzzi, Italy
MAIN THEMES
14:30-16:00 hr
THEME 1: RENAL INJURY AND REPAIR
Mechanisms of Epithelial Cell Injury
Libertador C Room
Chairpersons:
W Couser, US
V Tesar, Czech Republic
Adhesion molecules
J. Bonventre, US
Mediators of damage
L. Yu, Brazil
Apoptosis and necrosis
S. Shah, US
Calcium and cell injury
C.I. Edelstein, US
THEME 2: DIABETES AND THE KIDNEY
Genetic Markers of Diabetic Nephropathy (sponsored by Total Renal Care Inc.)
San Telmo Room
Chairpersons:
R. Zatz, Brazil
F. Berthoux, France
Introduction
W. Keane, US
G Protein gene polymorphism
W. Siffert, Germany
Renin angiotensin system: Gene polymorphism
Y. Tomino, Japan
Blood pressure control in the United Kingdom Prevention of Diabetes Study
R. Bilous, UK
THEME 3: DIALYSIS
When Should Renal Replacement Therapy for ESRD by initiated (sponsored by
Gambro AB)
Libertador A and B Rooms
Chairpersons:
C. Jacobs, France
M. Salda�a, El Salvador
Medical and economic outcomes: early versus late referral
R. Sesso, Brazil
Control of uremic symptoms by timely initiation of dialysis
C. Jacobs, France
Update on erythropoietin
F. Valderr�bano, Spain
Nutrition in dialysis patients
W. Mitch, US
THEME 4: TRANSPLANTATION
Issues in Renal Transplantation (sponsored by Novartis)
Retiro Room
Chairpersons:
D. Briggs, US
S. Franco, Paraguay
Outcome data in South America
F. Gonzalez, Uruguay
Unrelated living donors: medical issues
E. David-Neto, Brazil
Unrelated living donors: ethical considerations
J. Briggs, UK
Strategies to improve organ donation.
L. Hunsicker, US
THEME 5: HORMONES AND THE KIDNEY
Receptors, Non-Peptide Antagonists, Signaling and Receptor Response (Sponsored
by Yamanouchi Pharm Co.)
Golden Hall Room
Chairpersons:
D. Bichet, Canada
S. Lin, China
Dual function membrane transporters / retroviral receptors
M. Kavanaugh, US
Vasopressin, vasopressin-receptors, and non-peptide antagonists
D. Bichet, Canada
Angiotensin 11 receptors and signaling
E. Clauser, France
Alterations in vitamin D and Calcium receptors
in secondary hyperparathyroidism
E. Slatopolsky, US
COFFEE BREAK
16:00-16:30 hr
CONTINUOUS MEDICAL EDUCATION
16:30-18:30 hr
WATER AND ELECTROLYTE METABOLISM
Libertador A Room
Moderators:
T. Berl, US
R. Narins, US
Nephrogenic diabetes insipidus: new aspects of pathogenesis, diagnosis and therapy
D. Bichet, Canada
Managing hyperkalemia in azotemic patients
K. Kamel, Canada
SIADH: new aspects of pathogenesis and management
T. Bell, US
Metabolic acidosis
R. Narins, US
METABOLISMO DEL AGUA Y ELECTROLITOS
Sal�n Libertador C
Moderadores:
J. Ayus, US
A. Vaidiverso, Chile
Consecuencias metab�licas y neurol�gicas de hipernatremia
J. Ayus, US
Acidosis metab�1ica
C. Caramelo, Spain
Nuevos aspectos de la hipocalcemia
H. Cordova, Puerto Rico
Alcalosis metab�1ica y fallo renal
A. Valdivieso, Chile
RENAL PATHOLOGY
Retiro Room
Moderators:
C. Tisher, US
J. Weening, The Netherlands
Immunopathology of glomerulonephritis
J. Weening, The Netherlands
Acute nephritic syndrome
K. Assmann, The Netherlands
Nephrotic syndrome and asymptomatic proteinuria
Agnes Fogo, US
Transplant histopathology
C. Tisher, US
PATOLOGIA RENAL
Sal�n Libertador B
Moderadores:
S. Mezzano, Chile
H. Rennke, US
Nefropat�a por IgA
J. Egido, Spain
Glomerulopat�a membranosa
S. Mezzano, Chile
Glomerulonefritis aguda
H. Rennke, US
Histopatalog�a del ri�on transplantado
J. Pinto, Venezuela
HEMODIALYSIS
San Telmo Room
Moderators:
A. Davison, UK
F. Port, US
Daily home dialysis
T. Depnet, US
Acute renal failure: intermittent versus continuous dialysis
E. Paganini, US
Dialysis outcome: the experience in Japan
T. Shinzato, Japan
Dialysis dose and outcome
F. Port, US
HEMODIALISIS
Sal�n Fiestas (Hotel Marriott)
Moderadores:
R. Carlini, Venezuela
C. Najun, Argentina
Hepatitis C en el paciente en di�lisis
F. Carrera, Portugal
Aspectos nutricionales
S. Acchiardo, US
Anemia
M. Rothstein, US
Di�lisis continua vs intermitente en fallo renal agudo
J. Bosch, US
CASE PRESENTATION
Auditorium Room
Moderator R. Toto, US
Discussants:
W. Henrich, US
J. Cunningham, UK
P. Maxwell, UK
PRESENTACION DE CASOS
Sal�n Golden Horn
Moderador:
M. Martinez-Maldonado, US
Discutidores:
C. Caramelo, Spain
J. C. Ayus, US
H. Adrogue, US
NOVEL THERAPEUTICS IN NEPHROLOGY
19:00-20:00 hr
AT1 - RECEPTOR BLOCKADE
A NOVEL THERAPEUTIC APPROACH (sponsored by ASTRA)
Libertador B Room
Chairpersons:
C. Johnston, Australia
L. Ruilope, Spain
Introduction
C. Johnston, Australia
Renal Functional Response to A Tl Receptor Blockade in Normal and Hypertensive
States
G. Navar, Spain
The Importance of RAS in the Progression of Chronic Renal Failure
C. Johnson, Australia
The Role of RAS Blockade in Reducing Cardiac and Renal
Risk
L. Ruilope, Spain
SYMPOSIA 08:00-10:00 hr
RENAL STONES
Libertador Room
Chairpersons:
Ita Pfeferman Heilberg, Brazil
J. Weisinger, Venezuela
New Pathological aspects of hypercalciuria
D. Bushinsky, US
Modulators of crystallization and particle retention
B. Hess, Switzerland
Nutritional aspects of renal stone disease
J. Weisinger, Venezuela
New developments in the management of renal stone disease
Ita Pfeferman Heilberg, Brazil
NUTRITION EFFECTS ON RENAL DEVELOPMENT,
FUNCTION
AND BLOOD PRESSURE REGULATION 1
Retiro Room
Chairpersons:
J. Benabe, Puerto Rico
Claudie Merlet-Benichou, France
Vitamin A and kidney organogenesis
Claudie Merlet-Benichou, France
Fetal nutrition and programming of hypertension
G. Celsi, Sweden
Nutrition and development of water transport
M. Bonilla-F�lix, Puerto Rico
Dietary protein and regulation of urea transport
J. Sands, US
_________________________
Sponsored by Yamanouchi Pharm Co
AGE AND THE KIDNEY
San Telmo Room
Chairpersons:
L. Ferder, Argentina
D. Rodriguez-Puyol, Spain
Glomerular hemodynamics in the elderly
Christine Baylis, US
Renal fibrosis and sclerosis in aging
Maria del Carmen Iglesias, Spain
Water metabolism in the elderly
M. Levi, US
Clinical and therapeutic consequences of renal aging
J. Mac�as-N�nez, Spain
Differentiation of kidney arterioles
A. Gomez, US
Mechanisms of tubulogenesis
S. Nigam, US
Gene differentiation and cyst formation
Patricia Wilson, US
RENAL ECONOMICS: COST OF RENAL CARE
AN INTERNATIONAL PERSPECTIVE
Auditorium Room
Chairpersons: J. Dirks, Canada
Introduction
J.H. Dirks, Canada
Economic issues in ESRD care in Canada
D. Mendelssohn, Canada
Perspective: renal care costs in the USA
P. Held, US
Renal care costs in Europe
N. Lameire, Belgium
Renal care costs in the developing world: the India experience
V. Jha, India
Renal care costs in South America
M. Riella, Brazil
DISCUSSION
COFFEE BREAK 10:00-10:30 hr
PLENARY SESSION 10:30-11:30 hr Libertador, Retiro and San Telmo Rooms
AN Richards Award
Hans Ussing, Denmark
Introduced by R. Berliner, US
Isidore Edelman, US
Introduced by T. Andreoli, US
ISN General
Assembly part I
(for agenda click here)
EDUCATIONAL PROGRAM FOR CLINICAL TRIALS 11:30-14:00 hr
SESSION I
Fiestas Room (Marriott Plaza Hotel)
Chairpersons:
D. De Zeeuw, The Netherlands
J. Walls, UK
ISN commission on international clinical trials
S. Massry, US
When is a clinical trial indicated?
B. Kasiske, US
Could metanalysis be a substitute to a clinical trial?
D. Fouque, France
Fundamentals of design, hard and surrogate end points and statistical
analysis of a clinical trial
C. Bagnet, UK
How could an international consortium enhance the performance of clinical
trials?
R. Schrier, US
Potential use of the intent in conducting clinical trial
R. Barsoum, Egypt
DISCUSSION
POSTER SESSION 11:30-14:00 hr
(11:30-12:30 poster discussion)
Catalinas and San Isidro Rooms
MAIN THEMES 14:00-16:00 hr
THEME 1: RENAL INJURY AND REPAIR
Repair of Epithelial Cell Injury
Libertador C Room
Chairpersons:
J. Bonventre, US
T. Nagasawa, Japan
Role of inflammation
M. de Broe, Belgium
Role of growth factors
R. Hirschberg, US
Fibrosis: the dark side of repair
W. Couser, US
Role of vasoactive systems
G. Wolf, Germany
THEME 2: DIABETES AND THE KIDNEY
Mechanisms of Injury in Diabetic Nephropathy 2
San Telmo Room
Chairpersons:
W. Keane, US
H. Castillo, Peru
Progression promoters in type I diabetes mellitus
P. Rossing, Denmark
Role of TGF-R in diabetic renal damage
F. Ziyadeh, US
Glycation products and renal injury
M. Cooper, Australia
Vascular endothelial growth factor (VEGF) and diabetic nephropathy
R. Gilbert, Australia
_________________________
2 Sponsored by Total Renal Care Inc
THEME 3: DIALYSIS
Optimizing Outcomes with Long Term Peritoneal Dialysis 3
Libertador A and B Rooms
Chairpersons:
M. Riella, Brazil
D. Sanz Guajardo, Spain
Can the peritoneum be an efficient substitute for renal function?
B. Rippe, Sweden
How to prescribe automated peritoneal dialysis
J. Diaz-Buxo, US
Monitoring of adequacy
P. Blake, Canada
Do diabetics do better or worse on continuous ambulatory peritoneal
dialysis?
M. Riella, Brazil
THEME 4: TRANSPLANTATION
Immunobiology in Transplantation
Retiro Room
Chairpersons:
F. Cantarovich, Argentina
G. Mejia, Colombia
Allorecognition: Direct and indirect pathways
M. Sayegh, US
HLA update
G. Opelz, Germany
Prospects for tolerance
M. Suthanthiran, US
Pathways for T-cell activation
F. Lakkis, US
_________________________
3 Sponsored by Gambro AB
4 Sponsored by Novartis
THEME 5: HORMONES AND THE KIDNEY
New Advances in the Renin Angiotensin System
Golden Horn Room
Chairpersons:
A. Kurtz, Germany
J. Rodicio, Spain
Renal actions of angiotensin II
L. Navar, US
Macula densa control of the renin-angiotensin system
J. Schnermann, US
Regulation of angiotensin II receptors
R. Harris, US
Genetic disruption of the renin-angiotensin system
S. Umemura, Japan
COFFEE BREAK 16:00-16:30 hr
CONTINUOUS MEDICAL EDUCATION 16:30-18:30 hr
URINARY TRACT INFECTION FAMILIAL
MEDITERRANEAN FEVER
Libertador A Room
Moderators:
R. Barsoum, Egypt
W. H�rl, Austria
Diagnosis and management of urinary tract infection
W. H�rl, Austria
Vesicourethral reflux in children: its role in management
M. Linshaw, US
Ambulatory care of urinary tract infection
C. Naqvi, Pakistan
Familial Mediterranean Fever
C. Sungur, Turkey
INFECCI�N DEL TRACTO URINARIO
Sal�n Libertador C
Moderadores:
R. Jurado, EEUU
P. Castellanos, Honduras
Diagnostico y manejo de la infecci�n del tracto urinario
R. Jurado, EEUU
Manejo de al infecci�n urinaria de reflujo
R. Exeni, Argentina
Infecci�n y litiasis
Michaelle L�pez, Venezuela
Pronostico de las infecci�nes urinarias
J. Martinez Salas, Colombia
PERITONEAL DIALYSIS
Retiro Room
Moderators:
N. Lameire, Belgium
P. Blake, Canada
Selection criteria
Y. Kawaguchi, Japan
Physiology of peritoneal membrane
B. Rippe, Sweden
Adequacy of PD solutions
A. Breborowicz, Poland
DI�LISIS PERITONEAL
Sal�n Libertador B
Moderadores:
P. Amair, Venezuela
A. Locatelli, Argentina
Reconocimiento y manejo de infecci�nes
J. de Arteaga, Argentina
Adecuacion de di�lisis peritoneal
J. Bevilacqua, Brasil
Di�lisis peritoneal de alto flujo
J. Diaz-Buxo, EEUU
Complicaciones a largo plazo
J. Dominguez, Venezuela
MOLECULAR BIOLOGY FOR CLINICAL
NEPHROLOGISTS
San Telmo Room
Moderators:
H. Murer, Switzerland
S. Sasaki, Japan
Overview and introduction
H. Murer, Switzerland
Diseases to illustrate the molecular approach
a. X-linked hypophosphatemia/hereditary vitamin D dependent rickets
Susan Tenehouse, Canada
b. Amino aciduria (cystinuria)
M. Palacin, Spain
c. Gitelman's and Bartter's Syndrome
H. Seyberth, Germany
BIOLOG�A MOLECULAR PARA NEFR�LOGOS
Sal�n Golden Horn
Moderadores:
Arlyn Garcia-P�rez, EEUU
M. Orias, Argentina
Resumen y puesta al dia
Arlyn Garcia-P�rez, EEUU
Reductasa de aldosa: de diabetes mellitus a regulaci�n osmotica
Arlyn Garcia-P�rez, EEUU
Transporte s�dico: de diur�ticos a mol�culas y enfermedades
G. Gamba, Mexico
Canales de potasio y y regulaci�n del tono vascular
M. Orias, Argentina
CASE PRESENTATION
Auditorium Room
Moderator: R. Toto, US
Discussants: W. Henrich, US
J. Cunningham, UK
P. Maxwell, UK
PRESENTACI�N DE CASOS
Salon Fiestas (Marriott Hotel)
Moderador: M. Martinez-Maldonado, EEUU
Discutidores: C. Caramelo, Espa�a
J. Ay�s, EEUU
H. Adrogue, EEUU
NOVEL THERAPEUTICS IN NEPHROLOGY
19:00-20:00 hr
HYPERTENSION AND RENAL DISEASE
A Case for Rigorous Treatment 5
Libertador B Room
M. Epstein, US
__________________________
5 Sponsored by Astra
CARDIOVASCULAR DISEASE AND CHRONIC RENAL
INSUFFICIENCY:
IMPLICATIONS FOR FUTURE 6
Libertador C Room
Chairpersons:
W. Keane, US
S. Massry, US
The National Kidney Foundation Initiative on Cardiovascular Disease:
Pathogenesis and Treatment
J. Kopple, US
Proteinuria: A Risk Factor for Cardiovascular Morbidity and Mortality in
Diabetes and Non-diabetic Patients
W. Keane, US
The Influence of Anemia on Cardiovascular Morbidity and Mortality
A. Collins, US
The Role of Homocysteine as a Risk for Cardiovascular Disease
C. Wilcox, US
_________________________
6 Sponsored by Total Renal Care
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SYMPOSIA 08:00-10:00 hr
ENDOTHELINS
Libertador Room
Chairpersons:
D.E. Kohan, US
P. Marsden, Canada
Endothelin biology: gene targeting and transgenic strategies
D. Kohan, US
Endothelin converting enzymes
P. Marsden, Canada
Endothelins in chronic renal disease
Ariela Benigni, Italy
Clinical trials using Endothelin antagonists in cardiorenal disease
D. Brooks, US
INFECTION AND THE KIDNEY
Retiro Room
Chairpersons:
K-N. Lai, China
B. Rodriguez-Iturbe, Venezuela
Pathophysiology of cryoglobulinemia in hepatitis C virus nephropathy
L. Schifferli, Switzerland
Clinicopathologic features of hepatitis B virus nephropathy
K-N. Lai, China
HIV nepropathy: human data and murine models
J. Winston, US
Serological markers of streptococcal infection in acute glomerulonephritis
S. Batsford, Germany
EMERGING THERAPIES FOR KIDNEY DISEASES
San Telmo Room
Chairpersons:
K. Badr, US
E. Imai, Japan
Targeting of the TGF-b pathway
Y. Isaka, Japan
Metalloproteinase inhibitors
H. Marti, Switzerland
Chimeric proteins for the modulation of apoptosis during renal
inflammation
U. Kunzendorf, Germany
5-lipoxygenase activating protein inhibitors in human glomerulonephritis
K. Badr, US
NEONATAL NEPHROLOGY
Golden Horn Room
Chairpersons:
Anita Aperia, Sweden
I. Ichikawa, US
Molecular events in urogenital development
J. Barasch, US
Mechanisms of congenital anomalies of the kidney and urinary tract
I. Ichikawa, US
Role of cytokines in the development of multicystic dysplastic kidneys
D. Matsell, Canada
Development of normal and cystic renal epithelia
A. Woolf, UK
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MECHANISMS OF RENAL DISEASE IN ABORIGINAL
POPULATIONS
Auditorium Room
Chairpersons:
J. Dirks, Canada
D. Pugsley, Australia
Introduction
D. Pugsley, Australia
Renal disease and the environmental
Wendy Hoy, Australia
The impact of diabetes
R. Nelson, US
Hypertensive renal disease in African Americans
L. Agodoa, US
Epidemiological strategy
R. Plata, Bolivia
COFFEE BREAK 10:00-10:30 hr
PLENARY SESSION 10:30-11:30 hr in Libertador, Retiro and San Telmo Rooms
The Jean Hamburger Award
Awardee Robert Heptinstall, US
Presented by GS Hill, US
Awardee Barry Brenner, US
Presented by I Ichikawa, US
ISN General Assembly part II
(for
agenda click here)
POSTER SESSION 11:30-14:00 hr
(11:30-12:30 poster discussion)
Catalinas and San Isidro Rooms
EDUCATIONAL PROGRAM FOR CLINICAL
TRIALS 11:30-14:00 hr
SESSION II
Dorado Room (Marriott Plaza Hotel)
Chairpersons:
W. Keane, US
G. Bakris, US
What are the needs for clinical trials in nephrology?
Josephine Briggs, US
Lessons of the past:
a) Primary end points
The MDRD Study
S. Klahr, US
The Captopril Study
L. Hunsicker, US
b) Secondary analysis
T. Greene, US
Update on the status of ongoing and new clinical trials in nephrology
J. Kusek, US
Where do we go from here?
Moderator: S. Massry, US
Panel: G. Remuzzi, C. Ponticelli, D. De Zeeuw and J. Kopple
DISCUSSION
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SLANH SYMPOSIUM 11:30-14:00 hr
ACTUALIZACI�N EN IRC
Sal�n Fiestas (Marriott Plaza Hotel)
President: D. D�vila, Brasil
M. Acosta, Argentina
El problema del acceso vascular: como prevenir
V. Lorenzo, Espa�a
Adecuaci�n en hemodi�lisis: indicadores, aspectos clinicos y
resultados
J. Bosch, Brasil
Adecuaci�n en di�lisis peritoneal: indicadores, correlaci�n clinica y
resultados
R. Correa-Rotter, M�jico
La enfermedad �sea en el paciente en di�lisis: situaci�n actual del
problema
J. Cannata, Espa�a
La enfermedad cardiovascular del paciente en di�lisis: situaci�n actual
del problema
N. Mazzuchi, Uruguay
MAIN THEMES 14:00-16:00 hr
THEME 1: RENAL INJURY AND REPAIR
Glomerular and Tubular Interstitial Injury
Libertador C Room
Chairpersons:
R. Atkins, Australia
F. Valdes Canedo, Spain
Endothelial damage
Caroline Savage, UK
Toxicity of proteinuria
J. Walls, UK
Mechanisms of tubulointerstitial injury
E. Neilson, US
New approaches to therapy
E. Imai, Japan
THEME 2: DIABETES AND THE KIDNEY
Diabetes Epidemiology and Detection 1
San Telmo Room
Chairpersons:
H.H. Parving, Denmark
L. Rosivall, Hungary
Worldwide epidemiology of diabetic nephropathy
Europe - F. Locatelli
Japan - R. Kikkawa
US - F.K. Port
Summary - E. Ritz
Morphology of early changes in type II diabetic nephropathy
Paola Fioretto, Italy
Albumin excretion in pre-diabetes and type II diabetes
R. Nelson, US
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1 Sponsored by Total Renal Care Inc
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THEME 3: DIALYSIS
Cardiovascular Complications in Dialysis Patients 2
Libertador A and B Rooms
Chairpersons:
G. London, France
G. Alvarez, Dominican Republic
Cardiovascular risk factors
J. Lopez-Gomez, Spain
Cardiac remodeling
K. Amann, Germany
Vascular remodeling
G. London, France
Prevention and treatment of ischemic heart disease
Connie Manske, US
THEME 4: TRANSPLANTATION
Long Term Complications of Transplantation 3
Retiro Room
Chairpersons:
C. Agost Carreno, Argentina
M. Cerda, Costa Rica
Non-immune factors in chronic graft loss
P. Halloran, Canada
Viral infections: Hepatitis C and herpes type 8
B. Pereira, US
Cardiovascular disease in renal recipients
B. Kasiske, US
Renal disease in cardiac transplant recipients
W. Bennett, US
THEME 5: HORMONES AND KIDNEY
Kinins and the Kidney
Golden Horn Room
Chairpersons:
C. Vio, Chile
J. Cangriano, Puerto Rico
Pathophysiology of the renal kallikrein kinin system in regulation of
blood pressure
H. Margolius, US
Structural-functional relationships of the renal kallikrein kinin system
in health and disease
C. Vio, Chile
Mechanisms of kinin mediated growth in renal tissues
S. El-Dahr, US
Influence on renal electrolyte transport
D. Ploth, US
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2 Sponsored by Gambro AB
3 Sponsored by Novartis
COFFEE BREAK 16:00-16:30 hr
CONTINUOUS MEDICAL EDUCATION 16:30-18:30 hr
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RENAL TRANSPLANTATION
Libertador A Room
Moderators:
H. Helderman, US
D. Norman, US
Renal transplant recipient evaluation
G. Danovitch, US
Differential diagnosis and management of non-immunologic complications of
renal transplantation
H. Helderman, US
Transplant donor selection
B. Kasiske, US
Prevention and treatment of rejection
D. Norman, US
TRANSPLANTE RENAL
Sal�n Libertador C
Moderadores:
E. David-Neto, Brasil
Carmen Milan�s, Venezuela
Evaluci�n del receptor
E. David-Neto, Brasil
Selecci�n de donantes
Carmen Milan�s, Venezuela
Tratamiento y prevenci�n del rechazo
M. Arbelaez, Colombia
Manejo de complicaciones
J. Morales, Espa�a
PREGNANCY AND THE KIDNEY DISEASE
Retiro Room
Moderators:
J. Bernheim, Israel
Susan Hou, US
Impact of pregnancy on renal disease
J. Bernheim, Israel
Arterial hypertension and pregnancy
F. Kokot, Poland
Nephropathies associated with diabetes and lupus in pregnancy
Phyllis August, US
Pregnancy in dialysis and transplantation
Susan Hou, US
EMBARAZO RI�ON
Sal�n Libertador B
Moderadores:
M. Nadal, Argentina
N. Terragno, Argentina
Efecto del embarazo sobre la enfermedad renal
Liliana Voto, Argentina
Hipertensi�n arterial embarazo
J. Alfonso, Cuba
Diabetes y embarazo
L. Ort�, Espa�a
Embarazo en di�lisis y en transplante
Graciela Boccardo, Argentina
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UREMIC BONE DISEASE
San Telmo Room
Moderators:
T. Dru�ke, France
E. Slatopolsky, US
Pathogenesis of secondary hyperparathyroidism
K. Martin, US
Bone disease and renal transplantation
J. Cunningham, UK
Adynamic bone disease
H. Malluche, US
Prevention and treatment of uremic bone disease
K. �lgaard, Denmark
OSTEODISTROFIA RENAL
Sal�n Fiestas
Moderadores:
E. Bellorin-Font, Venezuela
J. Cannata, Espa�a
Manejo clinico de la osteodistrofia renal
J. Cannata, Espa�a
Patogenia del hiperaratiroidismo secundario
M. Rodriguez, Espa�a
Evoluci�n la enfermedad osea postransplante
E. Bellorin-Font, Venezuela
SPECIAL FORUM 16:30-18:30 hr
KIDNEY INTERNATIONAL
NEPHROLOGY FORUM
MALNUTRITION IN DIALYSIS: MALNOURISHMENT OR UREMIC
INFLAMMATORY RESPONSE?
Auditorium Room
Editor: N. Madias, US
Principal discussant: M. Riella, Brazil
NOVEL THERAPEUTICS IN NEPHROLOGY 19:00-20:00 hr
NEW VITAMIN D DERIVATIVE 22-OXA-CALCITRIOL
IN THE MANAGEMENT OF UREMIC HYPERARATHYRODISIM 4
Libertador A Room
Chairperson: E. Ogata, Japan
Introduction
E. Ogata, Japan
Assessment of 22-oxa-calcitriol
E. Slatopolsky, US
Results of clinical trials
T. Akizawa, Japan
CONTINUOUS ASSESSMENT OF HEMODIALYSIS
THERAPY 5
Libertador C Room
Chairpersons:
N. Levin, US
F. Valderrabano, Spain
On line clearance: A new tool to measure treatment dose
F. Gotch, US
Long term Clinical results
F. Locatelli, Italy
DISCUSSION
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5 Sponsored by CHUGAI
6 Sponsored by Fresenius Medical Care
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SYMPOSIA 08:00-10:00 hr
RENAL VASCULAR DISEASE
Libertador B Room
Chairpersons:
U. Blum, Switzerland
N. Kaplan, US
Diagnostic strategies for renovascular disease
N. Kaplan, US
Medical treatment: The DRASTIC study
Brigitte Clara Van Jaarsfeld, The Netherlands
Percutaneous transluminal angioplasty and stenting in atherosclerotic
renal artery disease
U. Blum, Switzerland
Ischemic nephropathy: Treatment controversies
C. Wilcox, US
EICOSANOIDS
Retiro Room
Chairpersons: M. Breyer, US
J. Capdevilla, US
Arachidonate metabolites
R. Stahl, Germany
Prostaglandin H2 synthase isoforms
P. Isakson, US
Prostanoid receptors: Insights from transgenic models
N. Breyer, US
Ecosanoids: The endless parade
J. McGiff, US
HEMOLYTIC UREMIC SYNDROME
San Telmo Room
Chairpersons:
G. Remuzzi, Italy
H. Repetto, Argentina
Verotoxin infection and endothelial cell activation
L. Monnens, The Netherlands
Pathogenesis
G. Remuzzi, Italy
Long term course
F. Spizzirri, Argentina
Transplantation
P. Broyer, France
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WATER AND AQUAPORINS
Golden Horn Room
Chairpersons:
C. Van Os, The Netherlands
G. Whittembury, Venezuela
Overview
S. Sasaki, Japan
Escape from the actions of vasopressin
Carolyn Ecelbarger, US
Aquaporin knockout models
A. Verkman, US
Diseases of aquaporins
S. Nielsen, Denmark
COFFEE BREAK 10:00-10:30 hr
PLENARY SESSION 10:30-11:30 hr
Claude Amiel Lecture
THE ROLE OF THE KIDNEY IN BLOOD PRESSURE VARIATION:
INSIGHTS FROM HUMAN GENETIC STUDIES
Lecturer: Richard Lifton, US
Introduced by S. Hebert, US
Libertador, Retiro and San Telmo Rooms
POSTER SESSION 11:30-14:00 hr
(11:30-12:30 poster discussion)
Catalinas and San Isidro Rooms
ASAMBLEA GENERAL DE LA SLANH 11:30-14:00 hr
PREMIOS V.R. MIATELLO Y MATILDE Y JOSE
AY�S
Sal�n Fiestas (Marriott Plaza Hotel)
MAIN THEMES 14:00-16:00 hr
THEME 1: RENAL INJURY AND REPAIR
Clinical and Therapeutic Aspects of Acute Renal Failure
Libertador C Room
Chairpersons:
C. Vaamonde, US
V. Sitprija, Thailand
Clinical overview of the pathogenesis of acute renal failure
R. Zager, US
Clinical spectrum of acute renal failure in Latin America
A. Seguro, Brazil
Clinical trials in prevention and reversal of acute renal failure
Brenda Kurnik, US
Progress in dialytic therapies for acute renal failure
J. Bosch, US
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THEME 2: DIABETES AND THE KIDNEY
Factors in the Progression of Diabetic Nephropathy 1
San Telmo Room
Chairpersons:
R. Kikkawa, Japan
S. Arze, Bolivia
Pathogenesis and treatment: lessons from animal models
R. Zatz, Brazil
Controversies in the antihypertensive treatment of diabetic
nephropathy
R. Schrier, US
Influence of glycemic control on the onset and progression of
diabetic renal disease
H. Parving, Denmark
Pancreatic and islet cell transplantation in progression and reversal of
diabetic nephropathy
M. Steffes, US
THEME 3: DIALYSIS
Current Issues in Hemodialysis 2
Libertador A and B Rooms
Chairpersons:
F. Valderrabano, Spain
N. Moreno, Panama
Duration versus dose of dialysis
B. Charra, France
Requiem for Kt/V
T. Parker, US
Reuse: fact or fiction
J. Vinhas, Portugal
Hepatitis C: isolation versus universal precautions
F. Carrera, Portugal
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1 Sponsored by Total Renal Care Inc
2 Sponsored by Gambro AB
THEME 4: TRANSPLANTATION
Future of Transplantation 3
Retiro Room
Chairpersons:
J. Morales, Spain
E. David-Netro, Brazil
Recently introduced immunosuppressive therapies
J. Grino, Spain
Emerging immune interventions
A. Krensky, US
Combined organ transplantation in metabolic diseases
W. van t Hoff, UK
Xenotransplantation
J. Platt, US
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THEME 5: HORMONES AND THE KIDNEY
Nitric Oxide and Intracellular Signaling
Golden Horn Room
Chairpersons:
J. Pleilschifter, Germany
N.A. Kurtzman, US
NO signaling by mitogen-stress-activated protein kinases
Andrea Huwiler, Germany
NO signaling and apoptosis
B. Bruene, Germany
Role of NO in experimental glomerulonephritis
Victoria Catell, UK
Role of NO in renal autoimmune disease
G. Gilkeson, US
COFFEE BREAK 16:00-16:30 hr
CONTINUOUS MEDICAL EDUCATION 16:30-18:30 hr
HYPERTENSION
Libertador A Room
Moderators:
F. Locatelli, Italy
L.M. Ruilope, Spain
New therapies for hypertension
L.M. Ruilope, Spain
Monogenic forms of hypertension
D. Warnock, US
Hypertension and progression of renal disease
F. Locatelli, Italy
Hypertension in transplant recipients
J. Curtis, US
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3 Sponsored by Novartis
HIPERTENSI�N
Sal�n Libertador C
Moderadores:
J. Herrera-Acosta, Mexico
Gloria Valdez, Chile
Formas monog�nicas
C. Pirola, Argentina
Hipertensi�n en el transplantado
J. Rodicio, Espa�a
Hipertensi�n y progresi�n de la enfermedad renal
A. Ribeiro, Brasil
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DIAGNOSIS AND MANAGEMENT OF
GLOMERULONEPHRITIS
San Telmo Room
Moderators:
J. Cameron, UK
R. Glassock, US
Role and pitfalls of the urinary sediment examination
T. Fogazzi, Italy
The value and role of serologic testing in the diagnosis of glomerulonephritis
R. Glassock, US
Proteinuria testing quantity and composition
J. Cameron, UK
Diagnostic role of renal biopsy in glomerulonephritis
A. Cohen, US
DIAGN�STICO Y MANEJO DE LA
GLOMERULONEFRITIS
Sal�n Libertador B
Moderadores:
Irene Noronha, Brasil
B. Rodriguez-Iturbe, Venezuela
Hematuria y proteinuria asintomatica
V. Garcia-Nieto, EEUU
Sindrome nefr�tico
A. Guasch, Espa�a
Glomerulonefritis r�pidamente progresiva
Irene Noronha, Brasil
Sindrome nefritico
B. Rodriguez-Iturbe, Venezuela
ACUTE RENAL FAILURE
Retiro Room
Moderators:
J. Bonventre, US
W. Lieberthal
The bioartificial renal tubule
D. Humes, US
Experimental models, clinical correlates
W. Lieberthal, US
Acute renal failure in the post-transplant patient
K. Solez, US
Renal replacement therapies in acute renal failure
C. Ronco, Italy
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INSUFICIENCIA RENAL AGUDA
Sal�n Fiestas
Moderadores:
P. Silva, EEUU
F. Lia�o, Espa�a
Evaluaci�n diagn�stica
P. Silva, EEUU
Epidemologia
F. Lia�o, Espa�a
Nefrotoxicidad de las drogas immunosupresoras
E. Burdmann, Brasil
Fallo renal agudo en rabdomiolisis
R. Correa-Rotter, M�jico
CASE PRESENTATION
Auditorium Room
Moderator: R. Toto, US
Discussants:
W. Henrich, US
J. Cunningham, UK
P. Maxwell, UK
PRESENTACI�N DE CASOS
Sal�n Golden Horn
Moderador: M. Martinez-Maldonado, EEUU
Discutidores:
C. Caramelo, Spain
J.C. Ay�s,EEUU
H. Adroque, EEUU
VIDEO LEGACY 19:00-20:00 hr
Libertador B Room
Chairperson:
K. Solez, Canada
S. Cameron, UK
Interviewee
D. Seldin, US
Date last modified: 09 Sep 1999