Kidney disease represents one of the most serious and costly chronic health conditions affecting Washington State residents. From the early stages of Chronic Kidney Disease (CKD) to the life-threateni...
The discovery of phospholipase A2 receptor (PLA2R) as the primary target antigen in primary membranous nephropathy (MN) by Beck et al. (New England Journal of Medicine, 2009) transformed the clinical ...
IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide and a leading cause of CKD progression to end-stage renal disease. The four-hit pathogenesis model, consolidated by Wy...
Prevention of CKD onset and progression is a critical public health priority. The ISN Global Kidney Health Roadmap (Levin et al., Kidney International, 2023) identified CKD prevention, early detection...
Acute kidney injury (AKI) is a common and serious clinical syndrome associated with significant morbidity and mortality, particularly in hospitalized and critically ill patients. Traditionally defined...
Kidney transplantation remains the optimal treatment for eligible patients with end-stage renal disease. However, the lifelong requirement for immunosuppressive therapy introduces significant risks of...
Chronic kidney disease is one of the most underestimated public health challenges of the twenty-first century. Affecting an estimated 850 million people worldwide, CKD progresses silently in the vast ...
Kidney disease — ranging from chronic kidney disease (CKD) to end-stage renal disease (ESRD/kidney failure) and kidney cancer — is a major public health burden in Arizona. The state’s kidney fai...
Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent hereditary kidney disease, affecting approximately 1 in 400 to 1 in 1,000 individuals. Mutations in PKD1 and PKD2, encoding p...
IgA nephropathy (IgAN) is a disease that quietly damages the kidneys over years, often decades, before many patients are even aware something is wrong. It is the most common form of primary glomerulon...