General Nephrology
January 2006
General Nephrology
Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia
Journal of Clinical Investigation : 1 December 2005
This study identifies a ECM protein, thrombospondin-1, as a mediator of ischemia-repefusion injury. This may prove to be a therapeutic target in the future for the treatment of ATN/AKI.
General Nephrology
A Trial of Contraceptive Methods in Women with Systemic Lupus Erythematosus
New England Journal of Medicine : 1 December 2005
At long last, the question of which contraceptive to use in women with SLE has been answered.
General Nephrology
Efficacy and Safety of Benazepril for Advanced Chronic Renal Insufficiency
New England Journal of Medicine : 12 January 2006
Are ACE-inhibitors effective (and safe) in preventing renal progression in patients with low GFR levels. This study from China attempts to answer this vexing question.
General Nephrology
Hepatocyte Growth Factor Is a Downstream Effector that Mediates the Antifibrotic Action of Peroxisome Proliferator-Activated Receptor- Agonists
Journal of American Society of Nephrology : 1 January 2006
Hepatocyte growth factor has been shown to ameliorate acute and chronic renal failure in animal models. PPAR-gamma agonists have been shown to limit fibrosis in animal models of CKD. This study provides evidence that the action of PPAR-gamma agonist is, in part, mediated via transciptional activation of the HGF gene.
General Nephrology
Use of Allopurinol in Slowing the Progression of Renal Disease Through Its Ability to Lower Serum Uric Acid Level
American Journal of Kidney Diseases : 1 January 2006
This small study suggests that lowering of serum uric acid levels with allopurinol may provide additional benefit in slowing the progression of CKD.
General Nephrology
Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury
Journal of Clinical Investigation : 1 January 2006
Bone morphogenetic protein (BMP)-7 has been shown in animal models to reverse the fibrosis of CKD. These authors show that a gene knock-out model of a BMP-7 antagonist which is expressed in the kidney (uterine sensitization-associated gene (USAG)-1) promotes improved renal function in both acute and chronic models of renal injury and may be another promising target for therapy in acute and chronic renal disease.
General Nephrology
Combined Oral Contraceptives in Women with Systemic Lupus Erythematosus
New England Journal of Medicine : 1 December 2005
At long last, the question of which contraceptive to use in women with SLE has been answered.
General Nephrology
Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis
The Lancet : 1 December 2005
This metaanalysis questions the premise that ACE-inhibitors and ARB's have protective effects beyond BP control on the progression of chronic kidney disease
General Nephrology
A pilot study using mycophenolate mofetil in relapsing or resistant ANCA small vessel vasculitis
Nephrology Dialysis Transplantation : 1 December 2005
This is a small study from Falk and Jennette suggesting the use of mycophenylate mofetil in some forms of ANCA-associated vasculitis.
General Nephrology
The leukotriene B4 receptor antagonist ONO-4057 inhibits mesangioproliferative changes in anti-Thy-1 nephritis
Nephrology Dialysis Transplantation : 1 December 2005
This study provides additional evidence for the role of prostanoids in mediating some forms of glomerulonephritis.
General Nephrology
The sialoadhesin (CD169) expressing a macrophage subset in human proliferative glomerulonephritis
Nephrology Dialysis Transplantation : 1 December 2005
This study identifies a subset of macrophages involved in mediating an experimental form of mesangial proliferative glomerulonephritis.
General Nephrology
Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays
Journal of Clinical Investigation : 1 December 2005
This study using proteome arrays to aid in the identification of pathogenetic auto-antibodies in lupus nephritis.
