Renin-Angiotensin Blockade in Polycystic Kidney Disease : The HALT PCKD trials

This is the second presentation of a series presented by ISN Education called the « Ten Minute » Update.

In this episode, Dr. Revekka Babayev presents an update (in collaboration with Dr. Jai Radhakrishnan) on « Renin-Angiotensin Blockade in Polycystic Kidney Disease: The HALT PCKD trials ». 

Please consult the presentation and its references below.



Parfrey, P.S., Bear, J.C., et al. The diagnosis and prognosis of autosomal dominant polycystic kidney disease. N Eng J Med, 1990. 323: p. 1085-1090.

Cornec-Le Gall, Audr?zet MP, et al. Type of PKD1 Mutation Influences Renal Outcome in ADPKD. J Am Soc Nephrol June 2013 24: 1006-1013

Chapman AB, Guay-Woodford LM, et al. Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort. Kidney International (2003) 64, 1035–1045

King, B., Reed, J., Bergstralh, E., Sheedy, P. and Torres, V., Quantification and longitudinal trends of kidney, renal cyst, and renal parenchyma volumes in Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol, 2000. 11: p. 1505-1511.

Grantham JJ, Torres VE, et al. Volume progression in polycystic kidney disease. N Engl J Med 2006, 354: 2122-­?30

Schrier RW, Brosnahan G, et al. Predictors of Autosomal Dominant Polycystic Kidney Disease Progression J Am Soc Nephrol November 2014 25: 2399-2418

Chapman, A., Johnson, A., Gabow, P. and Schrier, R., The renin-angiotensin-aldosterone system and autosomal dominant polycystic kidney disease. N Engl J Med 1990. 323: p. 1091-1096.

Jafar, TH, Stark PC, et al. The effect of angiotensin-converting-enzyme inhibitors on progression of advanced polycystic kidney disease. Kidney International (2005) 67, 265–271


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Last modified on Thursday, 17 September 2015 15:20

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