Observational studies in glomerular diseases suggest that proteinuria reduction translates to improved outcomes. Because of a dearth of high-quality studies supporting this association, proteinuria is not universally recognized as a surrogate end point. Barbour et al. report on the longitudinal measure of proteinuria that best predicts hard renal outcomes. Their finding that time-varying proteinuria is the most reliable proteinuria metric is a necessary step in establishing proteinuria as a surrogate end point.
Authors: Rupali S Avasare and Jai Radhakrishnan
Reference: Kidney Int 88: 1228-1230; doi:10.1038/ki.2015.301
Additional Info
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Language:
English -
Contains Audio:
No -
Content Type:
Articles -
Source:
KI -
Year:
2015 -
Members Only:
No