COMMENTARY: Peri-dialytic hypertension and hypotension: another U-shaped BP-outcome association

Park et al. performed a retrospective analysis of a large hemodialysis cohort to describe the relationship between pre- to postdialysis changes in BP and mortality. Their study demonstrated adverse outcomes associated both with large decreases and with any increase in blood pressure pre- to postdialysis. Although limitations exist in this analysis, which lacked intradialytic blood pressure measurements, the results support the ongoing concern about the potential adverse hemodynamic stress associated with conventional three-times-weekly hemodialysis.