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Monday, 07 September 2015 14:49

The battlefield at arteriovenous crossroads: invading arterial smooth muscle cells occupy the outflow tract of fistulas

By  Joris Rotmans
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There is an ongoing debate about the anatomical origin of the neointimal cells that are responsible for venous stenotic lesions in arteriovenous fistulas. Liang and co-workers show that vascular smooth muscle cells from the feeding artery contribute substantially to venous intimal hyperplasia in a murine AVF model. In addition, they show that increased Notch signaling is the driving force behind FSP-1-mediated migration of these cells to the venous outflow tract.


Authors: Joris I Rotmans and Taisiya Bezhaeva

Reference: Kidney International (2015) 88, 431–433; doi:10.1038/ki.2015.124

Additional Info

  • Language: English
  • Contains Audio: No
  • Content Type: Articles
  • Source: KI
  • Year: 2015
  • Members Only: No
Read 481 times Last modified on Monday, 07 September 2015 14:55

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