There is an ongoing debate about the anatomical origin of the neointimal cells that are responsible for venous stenotic lesions in arteriovenous fistulas. Liang and co-workers show that vascular smooth muscle cells from the feeding artery contribute substantially to venous intimal hyperplasia in a murine AVF model. In addition, they show that increased Notch signaling is the driving force behind FSP-1-mediated migration of these cells to the venous outflow tract.
Authors: Joris I Rotmans and Taisiya Bezhaeva
Reference: Kidney International (2015) 88, 431–433; doi:10.1038/ki.2015.124
Additional Info
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Language:
English -
Contains Audio:
No -
Content Type:
Articles -
Source:
KI -
Year:
2015 -
Members Only:
No