I would like to suggest, to study deeper, what are the bests treatmens of CKD Stage III: when one see NHANES III, we have in USA, almost 6 -7.000.000 of patients in this stage, but in Stage IV, we have only 400.000 and in Stage V=300.000.It is obvious that it is important to stop actions of Uremic Toxins, that are producing an severe Endothelial Dysfunction and increases up to 20 times, CV problems and Sudden Death(still not well explained)

I been suggesting, to study deeper , the bests treatments to stop actions of Uremic Toxins, , damaging Endothelium,, producing since the beginning of CKD III, Endothelial Dysfunction, and increasing CV Risk, 20 folds. over people, without CKD.When we check last NHANES, we can see, in Stage III,almost 7.000.000 patients with CKD, but in Stage IV=400.000patients and Stage V= 300.000 patients.The principal cause of death are CV Disorders and Sudden Death, being this last conditions, not yet understood

1/ Why only plain water is beneficial in decreasing the progression of GFR reduction rate? Will your study provide an answer to that ?
2/ There are some studies suggesting the increased water intake speeds up renal function deterioration - is it possible that the protection is beneficial in this regard only in healthy and initial CKD individuals but harmful at the most advanced CKD stages? Would your study indicate the CKD stage at which the increased water intake should be discouraged?

I m still confused about the fact that increased water intake decreases GFR. I believe it is so in CKD patients not a normal healthy individual.