Renal Pathology Case 16

By Hala Kfoury

font size decrease font size increase font size
Print
Be the first to comment!

Rate this item

(2 votes)

Case #16: H11-2873. C3 Glomerulonephritis.

Introduction

A 30 year old female with hypertension for 9 years, presented with gross hematuria for one month and is found to have proteinuria of 3.25g/day(normal 0.01-0.15g/day) and a serum creatinine of 141µmol/L (normal 53-106) . A renal biopsy is performed.

Go to Question 1

Discussion

Discussion Case 16

Question #1: The photomicrograph highlights the mesangial proliferation noted in the glomerulus. Different pattern of injury have been described in patients with C3 glomerulonephritis including mesangial proliferation.

Question #2: The diagnosis of C3 glomerulopathy is supported by the presence of strong mesangial and to a lesser degree capillary staining for C3 on the immunofluorescence studies with negative immunoglobulins. The electron microscopy study shows mainly subendothelial non-organized dense deposits. Studies regarding C3 glomerulonephritis showed a EG CD46 mutation.

Additional Info

Language: English
Contains Audio: No
Content Type: Case/Images
Year: 2014
Members Only: No

Read 1359 times Last modified on Monday, 13 October 2014 07:55

Published in Pathology

Tagged under

Hala Kfoury

Hala Kfoury Kassouf is Associate Professor of Pathology at the King Saud University Hospital in Saudi Arabia.

Latest from Hala Kfoury

Related items

More in this category: « Renal Pathology Case 15 Renal Pathology Case 17 »

Leave your comments

Post comment as a guest

Comments

No comments found

Global Operations Center

Rue des Fabriques 1
1000 Brussels, Belgium
Tel: +32 2 808 04 20
Fax: +32 2 808 4454
Email contact

Americas Operations Center

340 North Avenue 3rd Floor
Cranford, NJ 07016-2496, United States
Tel: +1 567 248 9703
Fax: +1 908 272 7101
Email contact

Follow Us: