The genetic composition of a donor impacts long-term allograft survival after kidney transplantation. Effects of the recipient’s genetic make-up, particularly variation in immune response pathway genes, are less certain. Bay et al. reveal improved graft survival in transplant recipients with lower copy numbers of the complement 4 gene (C4) after receipt of deceased-donor kidneys. Genomics breakthroughs in nephrology and immunology will likely revolutionize the field of transplant medicine.
http://www.nature.com/ki/journal/v84/n3/full/ki2013167a.html
COMMENTARY:
Genotypic variation and outcomes in kidney transplantation: donor and
recipient effects
Michael D Gautreaux and Barry I Freedman
Kidney Int 84: 431-433; doi:10.1038/ki.2013.167
CATEGORY: TRANSPLANTATION
Additional Info
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Language:
English -
Contains Audio:
No -
Content Type:
Articles -
Source:
KI -
Year:
2013 -
Members Only:
No